Quick Comparison
| Aloe Vera | Hemp Seed Oil | |
|---|---|---|
| Typical Concentration | Apply pure aloe vera gel or products containing high concentrations (>50% aloe). For sunburn: apply liberally and frequently. For daily use as a soothing moisturizer: apply after cleansing. Refrigerating aloe gel provides additional cooling relief. | Apply 2-5 drops as a moisturizer or mix with other products. Cold-pressed, unrefined oil is dark green with a nutty scent. Suitable for oily and acne-prone skin. Comedogenic rating: 0 (non-comedogenic). Use within 3-6 months and store refrigerated. |
| Application | Topical (gel, cream, lotion). Pure inner leaf gel or standardized extracts. Apply to clean skin. | Topical (pure oil). Cold-pressed, unrefined. Can also be taken orally as a supplement. |
| Research Papers | 10 papers | 7 papers |
| Categories |
Mechanism of Action
Aloe Vera
Acemannan (acetylated mannan polysaccharide) is the primary bioactive—it binds to macrophage mannose receptors and stimulates macrophage phagocytosis, cytokine release (IL-1, TNF-α), and fibroblast proliferation via growth factor induction, accelerating wound healing and granulation tissue formation. Acemannan also promotes keratinocyte proliferation and migration. Aloesin (a chromone) inhibits tyrosinase and tyrosinase-related protein-1 (TRP-1), providing mild brightening. Aloe-emodin has antibacterial activity against Gram-positive bacteria and antiviral effects. Salicylic acid naturally present in aloe inhibits cyclooxygenase (COX), providing mild anti-inflammatory and analgesic effects. The gel matrix forms a semi-occlusive film that reduces transepidermal water loss (TEWL). Aloe contains glucomannan, which acts as a humectant. Proteolytic enzymes (bradykinase) may contribute to anti-inflammatory activity. Use inner leaf gel to avoid anthraquinones in the latex that can cause irritation.
Hemp Seed Oil
Linoleic acid (55-60%) is key active — acne-prone skin has been shown to have 50% less in sebum compared to normal skin; deficiency may contribute to abnormal follicular keratinization and comedone formation. Topical supplementation normalizes sebum composition (linoleate is component of sebum triglycerides), reduces comedone formation, supports ceramide synthesis. GLA (gamma-linolenic acid, 2-4%) converts to DGLA, which inhibits pro-inflammatory leukotriene B4 synthesis (5-lipoxygenase competition) and is precursor to anti-inflammatory prostaglandin E1. 3:1 omega-6:omega-3 ratio considered optimal for skin. Natural vitamin E provides antioxidant protection. Comedogenic rating 0. Contains 0% THC/CBD. Ideal for acne-prone, inflamed, eczema-prone skin. Goes rancid within 3-6 months — store refrigerated.
Risks & Safety
Aloe Vera
Common
May cause drying if used alone (aloe lacks occlusive properties, so moisture can evaporate).
Serious
None from topical use.
Rare
Allergic contact dermatitis (especially to compounds in the latex/outer leaf, not the inner gel). Oral aloe vera is a separate concern with laxative effects.
Hemp Seed Oil
Common
Can feel slightly heavy for very oily skin. Goes rancid quickly if not stored properly.
Serious
None.
Rare
Very rare allergic reaction.
Full Profiles
Aloe Vera →
One of the oldest and most recognized soothing ingredients, used for millennia for burns, wounds, and skin irritation. Aloe vera gel contains over 75 active compounds including polysaccharides, vitamins, minerals, and enzymes. It provides immediate cooling, hydration, and anti-inflammatory relief. The evidence is strongest for wound healing, sunburn recovery, and moisturization.
Hemp Seed Oil →
Cold-pressed from Cannabis sativa seeds, hemp seed oil has an ideal 3:1 ratio of omega-6 to omega-3 fatty acids — the ratio considered optimal for skin health. It is rich in linoleic acid (which acne-prone skin is deficient in), gamma-linolenic acid (GLA, a potent anti-inflammatory), and natural vitamin E. Does not contain THC or CBD. One of the best oils for acne-prone, inflamed, or eczema-prone skin.